panflu Stats Forum Indexpanflu Stats
Influenza Pandemic Science, Statistics and News
 
 FAQFAQ   SearchSearch   MemberlistMemberlist   UsergroupsUsergroups   RegisterRegister 
 ProfileProfile   Log in to check your private messagesLog in to check your private messages   Log inLog in            Calendar

NEWS:
European agency endorses Baxter's bird flu vaccine

 
Post new topic   Reply to topic    panflu Stats Forum Index -> Vaccine Development
View previous topic :: View next topic  
Author Message
Mixin



Joined: 15 Dec 2007
Posts: 1419
:


Items

PostPosted: Fri Dec 19, 2008 9:58 pm    Post subject: European agency endorses Baxter's bird flu vaccine Reply with quote

By Bruce Japsen | Tribune staff reporter
3:55 PM CST, December 18, 2008

Baxter this afternoon said the Committee for Medicinal Products for Human Use of the European Medicines Agency issued a "positive opinion" for Baxter's Celvapan, a vaccine against H5N1 strains of avian influenza, also known as bird flu. The committee's endorsement is generally a precursor to approval by the European Union.

Baxter uses a cell-based technology that can produce vaccines quicker and in large quantities. The method could enable Baxter to produce dosages faster in the event of a flu pandemic, the company has said.

http://www.chicagotribune.com/business/chi-biz-baxter-bird-flu-vaccine-dec18,0,567144.story
Back to top
View user's profile Send private message
gs
Site Admin


Joined: 29 Jan 2006
Posts: 972
:
Location: Germany

Items

PostPosted: Sat Dec 20, 2008 3:32 pm    Post subject: Reply with quote

In addition to its culture method, the vaccine also makes no use of adjuvants,

In Europe, the United Kingdom and Austria signed contracts to stockpile Baxter's vaccine and that made of other companies.

Baxter is also in final stage clinical trials for a vaccine to prevent seasonal influenza that uses the company's cell-based technology, which could help boost production and prevent flu vaccine shortages that have arisen in recent years.

http://www.chicagotribune.com/business/chi-biz-baxter-bird-flu-vaccine-dec18,0,567144.story

Baxter expects final stage results of cell based seasonal PreFluCel flu-vax in Apr-Jun 2009.

In late 2004, Baxter had to suspend a final-stage human study of its seasonal flu vaccine
because it was causing fevers in some patients.



see also the recent trial in Germany
http://www.dradio.de/dlf/sendungen/forschak/886370/
(in German)
Baxter H5N1-vaccine tested in 100 volunteers in Cologne, Phase 3

204 google-hits for Celvapan


http://pandemicinformationnews.blogspot.com/

full text of Juni/2008 article in NEJM:
http://content.nejm.org/cgi/content/full/358/24/2573
_________________
------------------------------------------------------
--gs . Send me estimates of H5N1-deaths for the next 5 years (expectation value) !


Last edited by gs on Thu Dec 25, 2008 12:53 pm; edited 1 time in total
Back to top
View user's profile Send private message Send e-mail Visit poster's website
gs
Site Admin


Joined: 29 Jan 2006
Posts: 972
:
Location: Germany

Items

PostPosted: Sun Dec 21, 2008 8:01 am    Post subject: Reply with quote

http://www.praguepost.com/articles/2008/06/25/baxter-develops-bird-flu-vaccine.php
June 25.2008

In addition to its culture method, the vaccine also makes no use of adjuvants

“If you speak to experts within the WHO or within the ministries of health of various countries,
there’s a lot of concern in this direction, and that’s why some countries have already decided
to buy the vaccine directly from us or buy manufacturing capacity for them in the case of a
pandemic,” Ehrlich said.

### and, does Ehrlich confirm this concern ? Or could the Baxter production capacity be scaled up
### suitably in case of a severe pandemic with restricted biosafety,increased efforts and
### increased prices for the vaccine ?

The United Kingdom has already been one such country to purchase the vaccine, and Ehrlich said the Czech government has been in talks with Baxter as well.

The vaccine’s production time, is cut nearly in half with the cell-culture method,
from 22–28 weeks using eggs to 12 weeks with cell cultures.

The process using hen’s eggs also has a different effect on the immune system because of how it is manufactured. The virus in the hen’s egg is treated with bleach and delivers a “disrupted” version of the virus.

### so, could we take viruses from dead people in a pandemic, treat them with bleach
### and inhale them so to build up immunity ?

Baxter’s next step has been a phase III study with 550 subjects, the data from which has not been fully analyzed yet. The results of all three studies are being process edfor an application for licensure from the European Medicines Agency, which Ehrlich expects to be approved this fall.
_________________
------------------------------------------------------
--gs . Send me estimates of H5N1-deaths for the next 5 years (expectation value) !
Back to top
View user's profile Send private message Send e-mail Visit poster's website
Display posts from previous:   
Post new topic   Reply to topic    panflu Stats Forum Index -> Vaccine Development All times are GMT
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
panflu Stats topic RSS feed 


Powered by phpBB © 2001, 2005 phpBB Group
FREE FORUM HOSTING by AtFreeForum. Terms of Service - Privacy Policy
FASHION ACCESSORIES - BLING BLING - LADIES WATCHES - KOREAN CHILDREN CLOTHING - ONLINE BARGAIN STORE - FASHION JEWELLERIES