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LJ001: Broad Spectrum Antiviral

 
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Mixin



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PostPosted: Tue Feb 02, 2010 12:07 pm    Post subject: LJ001: Broad Spectrum Antiviral Reply with quote

the abstract is also posted in our summary forum
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We provide evidence that the small molecule- a rhodanine derivative that the researchers have dubbed LJ001- binds to both cellular and viral membranes, but its preferential ability to inactivate viral membranes comes from its ability to exploit the biogenic reparative ability of metabolically active cells versus static viral membranes, he (Dr. Lee) said. That is, at antiviral concentrations, any damage it does to the cell's membrane can be repaired, while damage done to static viral membranes, which have no inherent regenerative capacity, is permanent and irreversible.

In a proof-of-principle study published online in Proceedings of the National Academy of Sciences, the researchers have identified an antiviral small molecule that is effective against numerous viruses, including HIV-1, influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses and flaviviruses. These viruses cause some of the world's deadliest diseases, such as AIDS, Nipah virus encephalitis, Ebola, hemorrhagic fever and Rift Valley fever.

http://www.eurekalert.org/pub_releases/2010-02/uoc--rf020110.php
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