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A phase 3 trial of 550 adults found that an H5N1 influenza (avian flu) vaccine produced a strong immune response in adults, including those older than 60. The vaccine also produced a cross-reactive response to seasonal H1N1 strains but not seasonal A/H3N2 or B strains. Researchers gave the adults two doses 21 days apart of a Vero cell whole-virus vaccine without adjuvant. The researchers report, "The vaccine significantly increased the number of H5N1 specific and H5 haemagglutinin specific memory B cells, 6 months after the primary immunization." The immune response was not statistically different among those younger than 60, compared with the older cohort. The authors state that the vaccine "is capable of producing a good cross-clade cellular immune response," adding that "This is especially important since the clade from which a pandemic H5N1 strain will emerge in the future, if it does occur, will be difficult to predict."
http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/nov0510newsscan.html

study: Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans
Science Direct: http://tinyurl.com/255qjee
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