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Insect Cell Systems

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Joined: 15 Dec 2007
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PostPosted: Wed Aug 19, 2009 8:08 am    Post subject: Insect Cell Systems Reply with quote

This came from the Novel Vaccines Summit held in Rhode Island on Aug 17-18. The part I bolded was of interest because the different N-glycoslation patterns. Would this have any effect on the vax or its recipient?

Development of a Novel Baculovirus-Insect Cell System to Assess the Impact of Protein Glycosylation on Influenza Virus Subunit Vaccines

Donald Jarvis, Ph.D., Professor, Department of Molecular Biology, University of Wyoming

The baculovirus-insect cell system has been used to produce subunit and VLP HA vaccine candiDate against influenza viruses, which have been evaluated in human clinical trials. However, the recombinant HAs comprising these vaccine candiDate have N-glycosylation patterns derived from insect cells, which are not necessarily identical to those found on the native HA products. In this presentation, I will discuss our efforts to produce insect cell lines designed to provide more natural HA N-glycosylation patterns and to use these cell lines to evaluate the impact of insect versus higher eukaryotic N-glycoslation patterns on the efficacy of rHA subunit vaccine candiDate.
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